You are here

Genetic

From this September, boys of 12 and 13 will receive the HPV vaccine in all UK schools, hopefully preventing mouth, throat, penile and anal cancers caused by this oncovirus.

This occurs 11 years after a similar program for girls. The whole HPV vaccine program is now expected to prevent more than 100,000 cancer cases by 2058. This includes over 64,000 cervical cancers, almost 20,000 other cancers in women, and 30,000 cancers in men.

The use of molecular biomarkers in minimally invasive sampling opens a promising perspective for the early detection of endometrial cancer. This is the conclusion reached by the members of Screenwide research group, formed by researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO-Hospitalet).

Whilst it is widely accepted that smoking causes lung cancer, a lesser known fact is that ~6000 non-smokers die of lung cancer every year in the UK. One potential reason for this number is air pollution, according to a recent report by Public Health England (PHE). As these patients do not smoke, they are often overlooked when it comes to diagnosing lung cancer, and diagnosed late, with poor outcomes.

Healthy lung and lung with cancer 

To explain a person's actions in the present, it sometimes helps to understand their past, including where they come from and how they were raised. This is also true of tumors. Delving into a tumor's cellular lineage, a Ludwig Cancer Research study shows, can reveal weaknesses to target for customized therapies.

The findings, detailed in the April 24 issue of the journal Nature, also illustrate how knowledge of the biochemistry and microenvironment of the tissue from which a tumor arises can help predict the genetic alterations its cancer cells are likely to undergo.

Bottom Line: Six factors were associated with invasive recurrence of breast cancer after a diagnosis of ductal carcinoma in situ (DCIS), according to data from a meta-analysis.

Journal in Which the Study was Published: Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

New research demonstrating the clinical utility of Bio-Rad's Droplet Digital PCR (ddPCR) powered liquid biopsy will be presented this week during the 2019 American Association for Cancer Research (AACR) Annual Meeting in Atlanta, March 29-April 3. Many of the studies rely on the sensitivity, speed, and cost-effectiveness of ddPCR technology to measure blood-based tumor biomarkers in a reproducible way.

An interview with Professor Attila Lorincz from Queen Mary University of London (QMUL), discussing the development of a new cervical cancer test that is able to identify cervical cancer and pre-cancer in 100% cases.

How do we currently screen for cervical cancer in the UK?

The main method of cervical cancer screening is the Pap cytology (smear) test, however, we are now slowly transitioning to HPV screening. The cytology test is gradually being replaced and transitioned to a follow-up, or triage test.

 

Human papillomavirus (HPV) is widely known to cause nearly all cases of cervical cancer. However, you might not know that HPV also causes 70 percent of oropharyngeal cancer, a subset of head and neck cancers that affect the mouth, tongue, and tonsils. Although vaccines that protect against HPV infection are now available, they are not yet widespread, especially in men, nor do they address the large number of currently infected cancer patients.

A new blood test developed by University of North Carolina Lineberger Comprehensive Cancer Center researchers shows promise for tracking HPV-linked head and neck cancer patients to ensure they remain cancer-free after treatment.

The United States Preventive Services Task Force (USPSTF) has released new recommendations on screening for cervical cancer. These latest recommendations continue the trend of decreasing participant burden by lengthening screening intervals, making the "annual Pap" a historical artifact. Since its introduction 75 years ago, exfoliative cytology commonly known as the Pap test has been the "gold-standard" screening test for cervical cancer.

Pages

Subscribe to Genetic