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Women with early, low risk, hormone-driven breast cancer are less likely to have a recurrence of their disease if they have radiotherapy after surgery, as well as anti-hormone treatment, according to results from a trial that has followed 869 women for ten years.

Case Western Reserve University researchers and partners, including a collaborator at Cleveland Clinic, are pushing the boundaries of how "smart" diagnostic-imaging machines identify cancers--and uncovering clues outside the tumor to tell whether a patient will respond well to chemotherapy.

New findings about a fatal form of blood cancer could aid the development of new drugs with significantly less harmful side effects than existing chemotherapy.

The discovery could lead to novel treatments that efficiently eliminate blood cancer cells in acute myeloid leukaemia (AML), without harming healthy blood cells.

Researchers have discovered how a protein in the body plays a key role in AML - an aggressive cancer of white blood cells with very poor survival rates.

Women with early, low risk, hormone-driven breast cancer are less likely to have a recurrence of their disease if they have radiotherapy after surgery, as well as anti-hormone treatment, according to results from a trial that has followed 869 women for ten years.

New research demonstrating the clinical utility of Bio-Rad's Droplet Digital PCR (ddPCR) powered liquid biopsy will be presented this week during the 2019 American Association for Cancer Research (AACR) Annual Meeting in Atlanta, March 29-April 3. Many of the studies rely on the sensitivity, speed, and cost-effectiveness of ddPCR technology to measure blood-based tumor biomarkers in a reproducible way.

Osaka University-centered study examines large-scale population survey and identifies increase in cervical cancer rate, along with younger patients' surprising resistance to radiation therapy

Cervical cancer rates can be greatly reduced through preventive measures against the human papillomavirus (HPV) along with proactive cancer screening. Japan may be showing how ignoring that knowledge could prove hazardous, as it is the only advanced economy in which the cervical cancer rate is increasing. New research adds further nuance to this situation.

Cervical cancer can be insidious. Changes to the cervix are often detected with a pap smear, but for those with limited access to health care, cervical and vaginal cancers can go unnoticed for years--silently growing, spreading and invading other organs--and by the time they're detected, they may be so advanced that the patient's prognosis is poor and her treatment options few.

Immune checkpoint inhibitors, such as the anti-PD-1 antibody pembrolizumab, have become important tools for managing non-small-cell lung cancer (NSCLC). Assessing the level of programmed death ligand 1 (PD-L1) expressed by a tumor can help clinicians determine how the patient should be treated. A report in The Journal of Molecular Diagnostics describes a novel and rapid approach for quantifying PD-L1 expression levels in tumors that requires only small amounts of tissue that can be collected using minimally-invasive bronchoscopy techniques.

A joint research team from Russia and the U.K. has demonstrated the possibility of developing a new type of anti-neoplastic drugs based on nanoMIPs, or "plastic antibodies." NanoMIPs are synthetic polymers that can function as antibodies, selectively binding to target proteins on the surface of cancer cells. This approach could lead to a paradigm shift in the development of new methods for cancer treatment.

A new method predicts the course of HPV-negative head and neck cancer after radiation chemotherapy. According to a recent article in the journal ‘Clinical Cancer Research’, five microRNAs (miRNAs) can provide the decisive data. The work was conducted at the Helmholtz Zentrum München and the University Hospital of the Ludwig-Maximilians-Universität München (LMU) in close collaboration with the German Cancer Consortium (DKTK).

 

Irradiation plan of a head and neck tumor. © University Hospital of the Ludwig-Maximilians-Universität München

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