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Carnegie Mellon University researchers have developed a new method for delivering chemotherapy nanodrugs that increases the drugs' bioavailability and reduces side-effects.

Their study, published online in Scientific Reports, shows that administering an FDA-approved nutrition source prior to chemotherapy can reduce the amount of the toxic drugs that settle in the spleen, liver and kidneys.

An interview with David West, CEO and Hunter Jackson, CSO, Proscia, conducted by April Cashin-Garbutt, MA (Cantab)

How has the digitization of pathology slides impacted cancer diagnostics?

David: It is worth noting that in the U.S. and in many countries, digital pathology is still at a very early stage, compared to many other fields that were digitized 15 or 20 years ago such as radiology.

Fine-needle aspiration biopsy (FNAB), when performed by trained operators, and for the correct indications, is a safe and minimally invasive procedure, with an excellent 
diagnostic yield.


Definition, history and epidemiology

Arguably the best definition of FNAB is in a textbook of cytology by de May and reads ‘FNA biopsy can be defined as the removal of a sample of cells, using a fine needle, from asuspicious mass for diagnostic purposes’. 1

HDAC inhibitors, already widely used to treat cancer, may be an effective therapy for psoriasis as well, scientists report.

They have shown that HDAC3 inhibitors are particularly adept at increasing expression of aquaporin-3, or AQP3, a channel that transports glycerin, a natural alcohol and water attractor, which helps skin look better and aids healthy production and maturation of high-turnover skin cells.

Advanced imaging technologies have helped shift biopsy techniques away from more invasive approaches toward imaging-guided percutaneous-or through the skin-techniques, according to a new study appearing online and in the September print edition of the journal Radiology.

Biopsy-the removal of cells or tissue for microscopic examination-has a long history in medicine. The first percutaneous needle biopsy of the liver was reported in 1923, and the technique developed into an invaluable diagnostic tool in many organ systems.


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