A joint research team from Russia and the U.K. has demonstrated the possibility of developing a new type of anti-neoplastic drugs based on nanoMIPs, or "plastic antibodies." NanoMIPs are synthetic polymers that can function as antibodies, selectively binding to target proteins on the surface of cancer cells. This approach could lead to a paradigm shift in the development of new methods for cancer treatment.
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Combine a diet high in sugar with poor oral hygiene habits and dental cavities, or caries, will likely result. The sugar triggers the formation of an acidic biofilm, known as plaque, on the teeth, eroding the surface. Early childhood caries is a severe form of tooth decay that affects one in every four children in the United States and hundreds of millions more globally. It's a particularly severe problem in underprivileged populations.
In a "proof of concept" study, scientists at Johns Hopkins Medicine say they have successfully delivered nano-size packets of genetic code called microRNAs to treat human brain tumors implanted in mice. The contents of the super-small containers were designed to target cancer stem cells, a kind of cellular "seed" that produces countless progeny and is a relentless barrier to ridding the brain of malignant cells.
Results of their experiments were published online June 21 in Nano Letters.
Scientists searching for a therapy to stop the deadly and mostly untreatable lung disease, idiopathic pulmonary fibrosis (IPF), found a new molecular target that slows or stops the illness in preclinical laboratory tests.
A research team at Cincinnati Children's Hospital Medical Center reports its data in the journal Cell Reports. It found that a gene called FOXF1 inhibits the IPF disease process, which includes extensive scarring in lung connective tissues, hyperproduction of harmful cells called myofibroblasts and excessive lung inflammation.
Imagine a microscopic gold pill that could travel to a specific location in your body and deliver a drug just where it is needed. This is the promise of plasmonic nanovesicles.
These minute capsules can navigate the bloodstream, and, when hit with a quick pulse of laser light, change shape to release their contents. It can then exit the body, leaving only the desired package.
As cells with a propensity for cancer break down food for energy, they reach a fork in the road: They can either continue energy production as healthy cells, or shift to the energy production profile of cancer cells. In a new study published Monday (Oct. 23, 2017) in the journal Nature Cell Biology, University of Wisconsin-Madison researchers map out the molecular events that direct cells' energy metabolism down the cancerous path.
The findings could lead to ways to interrupt the process.