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Non-Small Cell Lung Cancer

Whilst it is widely accepted that smoking causes lung cancer, a lesser known fact is that ~6000 non-smokers die of lung cancer every year in the UK. One potential reason for this number is air pollution, according to a recent report by Public Health England (PHE). As these patients do not smoke, they are often overlooked when it comes to diagnosing lung cancer, and diagnosed late, with poor outcomes.

Healthy lung and lung with cancer 

Case Western Reserve University researchers and partners, including a collaborator at Cleveland Clinic, are pushing the boundaries of how "smart" diagnostic-imaging machines identify cancers--and uncovering clues outside the tumor to tell whether a patient will respond well to chemotherapy.

One small molecule that helps regulate gene expression plays a big role in keeping us safe from the machinations of cancer, scientists report.

In human lung cancer cells, they have shown low levels of the microRNA, miR-125a-5p, which enables the death of aberrant cells like cancer cells, correlates with high levels of the protein TIMP-1, which is already associated with a poor prognosis in patients with cancer.

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