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Osaka University-led study shows how a high-fat diet and systemic inflammation contribute to prostate cancer progression

Osaka - Inflammation and evasion of the immune system have been reported to be some of the new hallmarks of cancer. Notably, a high-fat diet (HFD) causes obesity and chronic inflammation, and studies conducted on mice have shown that HFD could be associated with progression and survival of prostate cancer. In human studies, inflammation and immune cells are also linked to prostate cancer.

Image-targeted biopsy of the prostate leads to a substantial increase in the proportion of prostate cores identified as high risk compared with standard transrectal ultrasound (TRUS)-guided biopsy, the results of a UK study indicate.

"This could lead to inflation in risk attribution as a consequence of deliberate oversampling of one part of the prostate - in other words, targeting," say Nicola Robertson (Royal Free Hospital, London) and colleagues. "New risk stratification models may be required for men who have pathology derived from image-directed biopsy strategies."

A new approach to analyzing prostate gland tissue may help address a major challenge in treating prostate cancer - determining which tumors are unlikely to progress and which could be life threatening and require treatment. In their report published in the journal Scientific Reports, Massachusetts General Hospital (MGH) investigators describe how cellular metabolites - proteins produced as the results metabolic processes - in apparently benign tissues from cancerous prostates not only can determine the grade and stage of the tumor but also can predict its risk of recurrence.

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